Treating Childhood Acute Lymphoblastic Leukemia without Cranial Irradiation
نویسندگان
چکیده
منابع مشابه
Cognitive outcomes following contemporary treatment without cranial irradiation for childhood acute lymphoblastic leukemia.
BACKGROUND Treatment of acute lymphoblastic leukemia (ALL) has included the use of prophylactic cranial irradiation in up to 20% of children with high-risk disease despite known cognitive risks of this treatment modality. METHODS Patients enrolled on the St Jude ALL Total Therapy Study XV, which omitted prophylactic cranial irradiation in all patients, were assessed 120 weeks after completion...
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متن کاملCranial irradiation in childhood lymphoblastic leukemia: time for reappraisal.
I Karmofsky D, Burchenal JH. Clinical evaluation ofchemotherapeutic agents in cancer. In: Macleod CM, ed. Evaluation ofchemotherapeutic agents. New York: Columbia University Press, 1949. 2 Hunt SM, McEwen J, McKenna SP. Measuring health status: a new tool for clinicians and epidemiologists. J R Coll Gen Pract 1985;35:185-8. 3 Grogono AW, Woodgate DJ. Index for measuring health. Lancet 1971 ;ii:...
متن کاملCentral nervous system relapse prophylaxis in acute lymphoblastic leukemia (ALL) intrathecal chemotherapy with and without cranial irradiation
Background: Central Nervous System (CNS) relapse in acute lymphoblastic leukemia was significantly decreased due to the use of new chemotherapyeutic agents, Intrathecal chemotherapy and cranial irradiation. The purpose of this study was to compare the effectiveness of intrathecal (IT) CNS chemotherapy alone versus combination of IT chemotherapy with cranial irradiation for prevention of CNS rel...
متن کاملLongitudinal linear growth and final height is impaired in childhood acute lymphoblastic leukemia survivors after treatment without cranial irradiation.
OBJECTIVE To evaluate long-term growth and final height (FH) in survivors of childhood acute lymphoblastic leukemia (ALL) who were treated without cranial radiation therapy and underwent evaluation of growth hormone (GH) status at the end of treatment. STUDY DESIGN Data on longitudinal growth (collected at the start of treatment, end of treatment, and 1 year thereafter) and FH of 67 adult sur...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2009
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa0900386